We formulated the guideline recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework (Table 1);14 they are summarized in Table 2. Along with each recommendation, we provide the supporting rationale and the values and preferences that the guideline committee prioritized, based on the existing literature and perspectives shared by primary care providers and patients.
About the Guideline
| Table 1 | |
| Strength of recommendation | Interpretation |
| Strong | The desirable effects or consequences of an intervention clearly outweigh its undesirable effects or consequences. |
| Conditional | The desirable effects or consequences of an intervention probably outweigh its undesirable effects or consequences. |
| Certainty of evidence | |
| High | High confidence that the true effect lies close to that of the estimate of effect. |
| Moderate | The true effect is likely to be close to the estimate of effect, but there is a possibility that it is substantially different. |
| Low | The true effect may be substantially different from the estimate of effect. |
| Very low | The true effect is likely to be substantially different from the estimate of effect. |